The iPS are a type of stem cells in adults, which are genetically reprogrammed to become embryonic stem cells. Pluripotent: Pluripotent stem cells like embryonic cells are easy to obtain.
Totipotent:Totipotent stem cells are less achievable compared to embryonic stem cells. Pluripotent:The development of totipotent stem cells is followed by the development of pluripotent stem cells. Totipotent:Totipotent stem cells are derived early. Pluripotent: Embryonic stem cells and iPS are pluripotent. Totipotent: The zygote and spore are totipotent. Pluripotent: The potential of differentiation of pluripotent stem cells is low compared to totipotent stem cells. Totipotent:The potential of differentiation is optimal in totipotent stem cells. Pluripotent:Pluripotent stem cells are differentiated into three germ layers in the embryo. Totipotent:Totipotent stem cells are capable of differentiating into more than 200 functionally distinct types of body cells in humans. Pluripotent:Stem cells which are capable of differentiating into any of the three germ layers are pluripotent. Totipotent:Stem cells which are capable of differentiating into all types of body cells are totipotent. Regeneration of organs using iPS is shown in figure 2.įigure 2: Regeneration of organs from iPS Difference Between Totipotent and Pluripotent Definition Some are partially pluripotent, though they are capable of forming three germ layers. They can be used to regenerate organs in vitro. The iPS are reprogrammed from adult stem cells by genetically modifying the cell in order to behave like embryonic stem cells. However, some cells like embryonic cells and induced pluripotent stem cells (iPS) are completely pluripotent. Mesoderm gives rise to bones, muscles, and blood. Ectoderm gives rise to epidermal tissues and the nervous system. Endoderm gives rise to the interior stomach lining, gastrointestinal tract, and lungs. Multipotent cells are capable of differentiating into several types of cells which are functionally related to each other. Each of these three germ layers is then differentiated into different organs and tissues by becoming multipotent. The three germ layers are endoderm, ectoderm, and mesoderm. Therefore, the totipotent stem cells in humans are capable of differentiating into any type of a body cell there are more than 200 distinct types of human body cells.Ī stem cell that is capable of differentiating into any of the three germ layers is considered as pluripotent. These three germ layers give rise to different types of specialized cells in the body by becoming multipotent. Then, inner cell mass becomes pluripotent by differentiating into three germ layers: endoderm, mesoderm, or ectoderm. Hence, the trophoblast and the inner cell mass are differentiated from the totipotent cells in the morula. This stage is referred to as the embryonic stage, and it has separated two cell masses called outer trophoblast and inner cell mass. After the implantation of blastocyte in the endometrium, the differentiation process begins. Zygote forms the morula, which is further divided to form the blastocyte. Zygote is divided by mitosis, generating identical cells which later become totipotent. In humans, the zygote is formed after the fertilization of the ovum by the sperm. But some differentiated cells are also capable of returning to totipotency state. Zygote and spore are two examples of totipotent cells. That means these cells contain the highest potential of differentiation. What is the difference between Totipotent and PluripotentĪ stem cell which is capable of giving rise to any kind of differentiated cells in a particular organism is considered as totipotent. – Definition, Differentiation, Uses, Examplesģ. The main difference between totipotent and pluripotent is that totipotent stem cells are capable of differentiating into all types of body cells whereas pluripotent stem cells are capable of differentiating into any of the three germ layers of the embryo. Since embryonic stem cells are commonly used for research, they can be used to regenerate organs in vitro. Totipotent stem cells give rise to pluripotent stem cells in the embryo. They are the first stage of differentiation. Totipotent stem cells are found in both spore and zygote. Both totipotent and pluripotent stem cells are found in the early stages of development. Totipotent and pluripotent are two types of potencies exhibited by stem cells in the body. Main Difference – Totipotent vs Pluripotent
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